From McCullers's birth in Columbus, Georgia, in 1917 to her death in upstate New York in 1967, The Lonely Hunter thoroughly covers every significant event in, and aspect of, the writer's life: her rise as a young literary sensation; her emotional, artistic, and sexual eccentricities and entanglements; her debilitating illnesses; her travels in America and Europe; and the provenance of her works from their earliest drafts through their book, stage, and film versions.

To research her subject, Virginia Spencer Carr visited all of the important places in McCullers's life, read virtually everything written by or about her, and interviewed hundreds of McCullers's relatives, friends, and enemies. The result is an enduring, distinguished portrait of a brilliant, but deeply troubled, writer.