Brenner's stories range in setting from the rural and southern (a rotating country music bar, a dog track/jai alai compound, a grocery store, a natural cold springs sinkhole) to the urban and high-tech (absurdly bureaucratic companies and academic departments and a food irradiation plant). Often young and tough women seeking to hone their survival sensibilities, Brenner's characters are a mix of the everyday and the fantastic: frustrated secretaries and scientists, a young supermodel, precocious children, fierce plumbers and mechanics, a psychic grandmother, an unhappy lottery winner, a desperate grocery-store mascot in an animal suit. And then there are the animals—real ones of all kinds who turn up at unlikely moments and often seem to be trying to help.